Discontinuous Administration of Clofazimine (B663) in Mycobacterium leprae Infections

Discontinuous Administration of Clofazimine (B663) in Mycobacterium leprae Infections

Summary The prophylactic and spaced administration of clofazimine was studied. The drug had an effect when given orally for 2 days immediately after infection, but had no effect when given 5 weeks before infection. When given once every 4 weeks from Day 70 to Day 140 after infection, the drug had a...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1971-06, Vol.137 (2), p.725-727
Hauptverfasser: Shepard, Charles C., Walker, Laura L., Van Landingham, Rosalind M., Redus, Martha A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Summary The prophylactic and spaced administration of clofazimine was studied. The drug had an effect when given orally for 2 days immediately after infection, but had no effect when given 5 weeks before infection. When given once every 4 weeks from Day 70 to Day 140 after infection, the drug had a distinct effect. It was also active when injected intraperitoneally on the day of infection.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-137-35653