Effects of α-(p-(Fluoren-9-ylidenemethyl)phenyl)-2-piperidineethanol (RMI 10,393) on Platelet Function 1

Summary RMI 10,393 is a new compound which inhibits aggregation of human platelets in plasma. It is effective against aggregation induced by ADP, thrombin, collagen, epinephrine, and serotonin. In the effective concentration range it also inhibits clot retraction, but does not cause activation of platelet factor 3. In an attenuated system activation of a platelet-derived procoagulant effect occurs, but this is not seen in the standard clotting system. RMI 10,393 has no effect on soluble clotting factors. A compound with such activity may have potential as an antithrombotic agent.