Biochemical Events During Interferon Synthesis in L Cells Infected with Newcastle Disease Virus 1

Summary The time of interferon induction in L cells has been shown to occur from 8 to 12 hr after infection with NDV. Although interferon synthesis represents the production of a new cellular protein, the rates of protein and nuclear RNA synthesis were found to actually undergo a rapid decrease following NDV infection. A comparison of the temperal relationship between alterations in overall macromolecular synthesis and interferon production indicated that the synthesis of L cell interferon occurred when macromolecular biosynthesis was considerably depressed.