Inhibtion of Endotoxin Fever by Reserpine.
Summary Reserpine in dosage sufficient to lower brain stem 5-hydroxytryptamine and norepinephrine suppresses endotoxin fever in rabbits. Pretreatment of rabbits with agents depleting only brain stem norepinephrine but not 5-hydroxytryptamine does not suppress febrile responses to endotoxin. An unexp...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1966-07, Vol.122 (3), p.746-749 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Summary
Reserpine in dosage sufficient to lower brain stem 5-hydroxytryptamine and norepinephrine suppresses endotoxin fever in rabbits. Pretreatment of rabbits with agents depleting only brain stem norepinephrine but not 5-hydroxytryptamine does not suppress febrile responses to endotoxin. An unexpected finding was the depletion of norepinephrine from the brain stem by guanethidine. |
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| ISSN: | 0037-9727 1535-3702 1535-3699 |
| DOI: | 10.3181/00379727-122-31242 |