A Neuropharmacological Investigation of the Convulsant Action of 4-Phenyl-4-Formyl-N-Methyl Piperidine (1762 IS)

Summary The hexosamine and hydroxyproline contents of aorta, lung, skin, kidney, skeletal muscle, bone and cartilage were determined in normal, scorbutic and insulin-treated scorbutic guinea pigs. In the scorbutic guinea pigs hexosamine content significantly increased in aorta, kidney, skeletal muscle and bone and no change was observed in lung, liver, cartilage and skin. Insulin treatment had no effect on these contents. Hydroxyproline content decreased significantly only in kidney and cartilage of scorbutic guinea pigs. Prolonged insulin treatment of the scorbutic animals produced a significant increase in the hydroxyproline contents of cartilage, kidney, lung and skin. The possible implications of the results have been discussed.