D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.3...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2021-05, Vol.41 (5), p.1013-1025, Article 0271678
Hauptverfasser:	Chen, Lin, Wei, Zhiliang, Chan, Kannie WY, Li, Yuguo, Suchal, Kapil, Bi, Sheng, Huang, Jianpan, Xu, Xiang, Wong, Philip C, Lu, Hanzhang, van Zijl, Peter CM, Li, Tong, Xu, Jiadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Animals Blood-Brain Barrier - metabolism Brain - diagnostic imaging Brain - metabolism Carbohydrate Metabolism, Inborn Errors - diagnosis Carbohydrate Metabolism, Inborn Errors - metabolism Carbohydrate Metabolism, Inborn Errors - physiopathology Cost-Benefit Analysis Disease Models, Animal Endocrinology & Metabolism Feasibility Studies Female Glucose - cerebrospinal fluid Glucose - metabolism Glymphatic System - metabolism Glymphatic System - physiopathology Hematology Life Sciences & Biomedicine Magnetic Resonance Imaging - economics Magnetic Resonance Imaging - methods Mice Mice, Inbred BALB C Mice, Inbred C57BL Monosaccharide Transport Proteins - deficiency Monosaccharide Transport Proteins - metabolism Neurosciences Neurosciences & Neurology Original Science & Technology Sensitivity and Specificity tau Proteins - metabolism Tauopathies - metabolism Tauopathies - pathology
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Zusammenfassung:	In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p
ISSN:	0271-678X 1559-7016 1559-7016
DOI:	10.1177/0271678X20941264