Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors : research article

Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors : research article

Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:South African journal of chemistry 2014-01, Vol.67 (1), p.71-79
Hauptverfasser: Chakravorty, Santanu, Klein, Hanna F, Van Otterlo, Willem A.L, Hodson, Luke E, Pelly, Stephen C, Fang, Zhizhou, Richters, Andre, Rauh, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Anthranilic acid
EGFR
Piperazines
Small molecule kinase inhibitors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.
ISSN:0379-4350
DOI:10.10520/EJC152901