Selective bromination of 4-chloro-1-indanone and synthesis of (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine : research article

Selective bromination of 4-chloro-1-indanone and synthesis of (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine : research article

The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chloro-1-indanone followed by reduction gave (4-ch...

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Veröffentlicht in:South African journal of chemistry 2010-01, Vol.63 (1), p.83-87
Hauptverfasser: Piltan, M., Badali, M., Jasouri, S., Khalafy, J.
Format: Artikel
Sprache:eng
Schlagworte:
Bromination
Cyanation
Daana Pharmaceutical Co
GABA(B) receptors
Indanone
Reduction
Urmia University
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Zusammenfassung:The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chloro-1-indanone followed by reduction gave (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine in quantitative yield.
ISSN:0379-4350