Synthesis and antimicrobial activity of some new α-aminophosphonates

Syntheses of new α-aminophosphonates 4a-l were achieved through a one-pot, three-component reaction process (the Kabachnik-Fields reaction). It involves the reaction with substituted salicylaldehydes, amines and dialkyl / diaryl phosphates in dry toluene at reflux temperature. The structures of the novel products were established by elemental analyses, IR, 1H, 13C and 31P NMR and mass spectroscopy. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antimicrobial activity.