Synthesis of Dinaphtho-dioxaphosphocin-8-oxides, Epoxides and Bisphosphonates

Synthesis of Dinaphtho-dioxaphosphocin-8-oxides, Epoxides and Bisphosphonates

Preparation of 8-substituted-16H-dinaphtho [2, 1-d:1', 2'-g] [1, 3, 2] dioxaphosphocin 8-oxides (5a-g) with an eight-membered phosphorus heterocyclic system (2) and their epoxides and bisphosphonates was accomplished by reacting 8-bromo-dinaphthophosphocin (2) with different mono and bis G...

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Veröffentlicht in:South African journal of chemistry 2007-01, Vol.60 (1), p.62-66
Hauptverfasser: Sankar, A.U. Ravi, Raju, C. Naga, Kumar, B. Siva, Kasthuraiah, Maddali, Reddy, C. Suresh
Format: Artikel
Sprache:eng
Schlagworte:
Antimicrobial activity
Dioxaphosphocin 8-oxides
Dioxaphosphocin bisphosphonates
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Zusammenfassung:Preparation of 8-substituted-16H-dinaphtho [2, 1-d:1', 2'-g] [1, 3, 2] dioxaphosphocin 8-oxides (5a-g) with an eight-membered phosphorus heterocyclic system (2) and their epoxides and bisphosphonates was accomplished by reacting 8-bromo-dinaphthophosphocin (2) with different mono and bis Grignard reagents (3a-g and 6) followed by oxidation with H2O2. Their structures were confirmed by elemental and spectral (1H, 13C and 31P NMR) data analysis. Some of these compounds are found to possess moderate antimicrobial activity.
ISSN:0379-4350