Halogenation-induced C-N bond activation enables the synthesis of 1,2--aryl furanosides deaminative cyclization

1,2- cis C -Aryl furanosides are prevalent in nature and exhibit significant biological activities. The 1,2- cis configuration is less favorable in terms of stereoelectronic and steric effects, making the synthesis of this type of skeleton highly challenging. Traditional methods for the synthesis of 1,2- cis C -aryl furanosides usually require complicated protection manipulations, resulting in lengthy synthetic routes and low overall efficiency. Here, we report a simple and highly applicable procedure for the synthesis of 1,2- cis C -aryl furanosides from unprotected aldoses via Petasis reaction and subsequent deaminative cyclization. Unprotected aldose mediated Petasis reactions yield linear 1,2- trans 1-aryl polyhydroxy amines. Halogenation of the amine motif activates the conventionally inert C-N bond and triggers the key stereoinvertive intramolecular substitution process, affording 1,2- cis C -aryl furanosides with excellent chemo- and diastereoselectivity. This procedure does not require the use of any sensitive reagents, and can be conducted in one-pot without precautions against oxygen or moisture, offering a streamlined approach to 1,2- cis C -aryl furanoside natural products and bioactive agents. A streamlined approach for the selective synthesis of 1,2- cis C -aryl furanosides from unprotected aldoses in two steps.