Photocatalyst-free, visible-light-induced regio- and stereoselective synthesis of phosphorylated enamines from -allenamides [1,3]-sulfonyl shift at room temperature

Herein, we report the first visible-light-induced strategy for the rapid synthesis of densely functionalized α- and γ-phosphorylated β-sulfonyl enamines in a regio- and stereoselective manner from N -sulfonyl allenamides and H-phosphine oxides. The transformation displays a broad substrate scope, wh...

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Veröffentlicht in:Chemical science (Cambridge) 2024-11, Vol.15 (43), p.17962-1797
Hauptverfasser: Guo, Jia-Dong, Korsaye, Feven-Alemu, Schutz, Dorian, Ciofini, Ilaria, Miesch, Laurence
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Zusammenfassung:Herein, we report the first visible-light-induced strategy for the rapid synthesis of densely functionalized α- and γ-phosphorylated β-sulfonyl enamines in a regio- and stereoselective manner from N -sulfonyl allenamides and H-phosphine oxides. The transformation displays a broad substrate scope, while operating at room temperature under photocatalyst- and additive-free conditions. In this atom-economical process, either terminal or substituted N -sulfonyl allenamides trigger an unprecedented N -to- C [1,3]-sulfonyl shift, relying on a dual radical allyl resonance and α-heteroatom effect in its triplet excited state. A plausible reaction mechanism is proposed which was supported by the outcomes of theoretical approaches based on Density Functional Theory (DFT) calculations. Herein, we report the first visible-light-induced strategy for the rapid synthesis of densely functionalized α- and γ-phosphorylated β-sulfonyl enamines in a regio- and stereoselective manner from N -sulfonyl allenamides and H-phosphine oxides.
ISSN:2041-6520
2041-6539
DOI:10.1039/d4sc05190d