Ultrasound-assisted magnetic dispersive micro-solid-phase extraction based on carbon quantum dots/zeolite imidazolate framework-90/polyvinyl pyrrolidone/FeO followed by high-performance liquid chromatography with ultraviolet detection for trace analysis of paracetamol and etodolac in human plasma
A four-part and sustainable nanocomposite composed of carbon quantum dots modified with zeolite imidazolate framework-90, polyvinyl pyrrolidone and magnetite (CQDs/ZIF-90/PVP/Fe 3 O 4 ) was fabricated and applied in ultrasound-assisted magnetic dispersive micro-solid-phase extraction (US-A-MDMSPE)....
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Veröffentlicht in: | RSC advances 2024-10, Vol.14 (45), p.33418-33428 |
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Zusammenfassung: | A four-part and sustainable nanocomposite composed of carbon quantum dots modified with zeolite imidazolate framework-90, polyvinyl pyrrolidone and magnetite (CQDs/ZIF-90/PVP/Fe
3
O
4
) was fabricated and applied in ultrasound-assisted magnetic dispersive micro-solid-phase extraction (US-A-MDMSPE). US-A-MDMSPE was followed by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) for extraction, enrichment and simultaneous low-level monitoring of paracetamol (PCM) and etodolac (EDL) in human plasma. To increase the extraction yield and improve the sensitivity, nanohybrid arrays of metal-organic frameworks and conductive polymers were immobilized on the surface of CQDs followed by magnetization. The nano-extractor was characterized
via
Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM) and energy-dispersive X-ray spectroscopy (EDX). The recent method provided limits of detection (LODs) of 0.16 and 0.09 ng mL
−1
for PCM and EDL, respectively. The calibration curve for PCM and EDL was linear in the range of 0.7-2000 ng mL
−1
and 0.5-1200 ng mL
−1
with a regression (
r
2
) value between 0.993 and 0.998, respectively. Acceptable precisions including intra-assay (≤6.9%) and inter-assay (≤8.3%) accuracies and notable accuracy (≤8.5%) were achieved to demonstrate the applicability of this method for the evaluation of the pharmacokinetic data of target drugs in human plasma.
Schematic diagram of the synthesis routes of CQDs/ZIF-90/PVP/Fe
3
O
4
. |
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ISSN: | 2046-2069 |
DOI: | 10.1039/d4ra04875j |