A metal-organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among the current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy in combating inflammation. However, the indeterminate structu...

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Veröffentlicht in:Nanoscale 2024-05, Vol.16 (19), p.946-9411
Hauptverfasser: Huang, Cheng, Deng, Yucen, Ma, Rongze, Ge, Hucheng, Gong, Fuzhong, Yang, Jinghui, Zhu, Xinyuan, Wang, Youfu
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Sprache:eng
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Zusammenfassung:In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among the current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy in combating inflammation. However, the indeterminate structures and limited enzyme-like activity exhibited by most developed nanozymes impede their clinical translation and therapeutic effectiveness. In this paper, we developed a nanozyme derived from a well-defined metal-organic cage (MOC). The oxidized MOC (MOC-O), containing pyridine nitrogen oxide moieties, exhibited effective cascade superoxide dismutase (SOD) and catalase (CAT)-like activities for scavenging reactive oxygen species (ROS). This ROS scavenging ability was confirmed through flow cytometry analysis using DCFH-DA in a hypoxia/reoxygenation (H/R) model, where MOC-O significantly alleviated oxidative stress. Furthermore, the administration of MOC-O resulted in preserved renal function during renal ischemia-reperfusion (I/R) injury due to downregulated oxidative stress levels and reduced cell apoptosis. An MOC-based cascade nanozyme with relatively definite structures was developed and it scavenged ROS to alleviate renal I/R injury.
ISSN:2040-3364
2040-3372
DOI:10.1039/d4nr00742e