An -vanillin scaffold as a selective chemosensor of PO and the application of neural network based soft computing to predict machine learning outcomes

O -Vanillin derived Schiff base 1-[( E )-(2-hydroxy-3-methoxybenzylidene) amino]-4-methylthiosemicarbazone (VCOH) has been synthesized for colorimetric and fluorescence chemosensors towards PO 4 3− ions. A fluorescence 'turn-on' sensing mechanism of VCOH towards PO 4 3− ions has been expla...

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Veröffentlicht in:New journal of chemistry 2024-08, Vol.48 (33), p.14642-14654
Hauptverfasser: Mudi, Naren, Samanta, Shashanka Shekhar, Mandal, Sourav, Barman, Suraj, Beg, Hasibul, Misra, Ajay
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Zusammenfassung:O -Vanillin derived Schiff base 1-[( E )-(2-hydroxy-3-methoxybenzylidene) amino]-4-methylthiosemicarbazone (VCOH) has been synthesized for colorimetric and fluorescence chemosensors towards PO 4 3− ions. A fluorescence 'turn-on' sensing mechanism of VCOH towards PO 4 3− ions has been explained due to emission from the VCO − ion formed upon transfer of the phenolic proton of VCOH to a PO 4 3− ion. The 1 : 1 stoichiometry between the VCOH probe and PO 4 3− ion is confirmed by Job's plot based on UV-vis titration. The limit of detection (LOD) of VCOH towards PO 4 3− ions is found to be 0.49 nM. The PO 4 3− ion sensing property of probe VCOH has been applied to prepare portable paper strips and for the analysis of real water samples. Fluorescence 'turn-on' and 'turn-off' responses of VCOH towards PO 4 3− and H + respectively have been used to construct a molecular logic gate. Fluorescence based sensing studies in which the concentration of analytes is adjusted over a broad range can be both laborious and expensive. In order to address these challenges, we have utilized various soft computing methods, including artificial neural networks (ANN), fuzzy logic (FL), and adaptive neuro-fuzzy inference systems (ANFIS), to appropriately model the 'turn-on' and 'turn-off' behaviors of the VCOH probe upon addition of PO 4 3− and H + respectively as well as to predict the experimental sensing data. O -Vanillin derived Schiff base 1-[( E )-(2-hydroxy-3-methoxybenzylidene) amino]-4-methylthiosemicarbazone (VCOH) has been synthesized for colorimetric and fluorescence chemosensors towards PO 4 3− ions.
ISSN:1144-0546
1369-9261
DOI:10.1039/d4nj02462a