Multiphase photochemistry in flow mode an integrated continuous stirred tank reactor (CSTR) approach

A new photochemical CSTR system capable of handling solids in scaled continuous processes is presented. High-power UV-LEDs are integrated in these CSTRs containing an insoluble base that aids in generating pyrazolines via cycloaddition between alkenes and in situ generated diazo species. Contrary to reported batch methods product degradation via ring contraction is suppressed whilst generating gram quantities of spirocyclic pyrazolines. This study highlights the application of a photo-CSTR cascade for the scalable and selective generation of pyrazolines under heterogeneous conditions.