Chalcogen bonding interaction between ebselen and nitrite promote -nitrosation of amines

Ebselen ( EbSe ), a therapeutically significant molecule, is shown to exhibit chalcogen bonding interaction with nitrite anion ( ONO − ). This report suggests that the σ-holes of EbSe are powerful for offering weak but influential interactions towards biologically relevant ONO − , thereby assisting oxidative transformations like N -nitrosation of aromatic amines. Ebselen ( EbSe ), a therapeutically significant molecule, is shown to exhibit chalcogen bonding interaction with nitrite anion ( ONO − ).