Modular access to sulfur substituted analogues of isocytosine photoredox catalysis

A photoredox approach for synthesizing sulfur-substituted analogues of isocytosine via coupling of modular phenyl propargyl chloride with thiourea has been reported. The resulting product with an amine group was found amenable to various late-stage modifications, providing access to a broad range of sulfur-containing isocytosine derivatives. A photoredox approach for synthesizing sulfur-substituted analogues of isocytosine via coupling of modular phenyl propargyl chloride with thiourea has been reported.