Silver/gold nanoalloy implant coatings with antibiofilm activity pH-triggered silver ion release
Implant infections are a major challenge for the healthcare system. Biofilm formation and increasing antibiotic resistance of common bacteria cause implant infections, leading to an urgent need for alternative antibacterial agents. In this study, the antibiofilm behaviour of a coating consisting of...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-07, Vol.6 (6), p.7729-7732 |
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Zusammenfassung: | Implant infections are a major challenge for the healthcare system. Biofilm formation and increasing antibiotic resistance of common bacteria cause implant infections, leading to an urgent need for alternative antibacterial agents. In this study, the antibiofilm behaviour of a coating consisting of a silver (Ag)/gold (Au) nanoalloy is investigated. This alloy is crucial to reduce uncontrolled potentially toxic Ag
+
ion release. In neutral pH environments this release is minimal, but the Ag
+
ion release increases in acidic microenvironments caused by bacterial biofilms. We perform a detailed physicochemical characterization of the nanoalloys and compare their Ag
+
ion release with that of pure Ag nanoparticles. Despite a lower released Ag
+
ion concentration at pH 7.4, the antibiofilm activity against
Escherichia coli
(a bacterium known to produce acidic pH environments) is comparable to a pure nanosilver sample with a similar Ag-content. Finally, biocompatibility studies with mouse pre-osteoblasts reveal a decreased cytotoxicity for the alloy coatings and nanoparticles.
AgAu nanoalloy particles deposited on Ti substrates release antimicrobial Ag
+
ions in the presence of an acidic biofilm microenvironment, providing an on-demand triggered antibiofilm activity. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d4cc01168f |