Synthesis of -fused cyclopentenone-pyrrolidine scaffolds sequential aza-Piancatelli and Conia-ene type reactions in one pot

A novel one-pot protocol that enables sequential execution of an aza-Piancatelli rearrangement and a Conia-ene type reaction has been developed under Lewis acid catalysis. Here, a combination of B(C 6 F 5 ) 3 and Cu(OTf) 2 , triethylamine, and triphenylphosphine yielded a wide range of cis -fused cyclopentenone-pyrrolidine scaffolds in one pot with good yields and diastereoselectivity. A novel diastereoselective one-pot protocol has been developed through sequential execution of an aza-Piancatelli rearrangement and a Conia-ene type reaction under Lewis acid catalysis.