Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation
We report a specific lysosome targeted light-responsive CO-releasing molecule ( Lyso-CORM ). Lyso-CORM is very stable under dark conditions. CO and singlet oxygen ( 1 O 2 ) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results d...
Gespeichert in:
Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-02, Vol.6 (15), p.298-211 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | We report a specific lysosome targeted light-responsive CO-releasing molecule (
Lyso-CORM
).
Lyso-CORM
is very stable under dark conditions. CO and singlet oxygen (
1
O
2
) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results demonstrated that
Lyso-CORM
showed good phototoxicity due to the synergistic effect of CO and
1
O
2
release, and its good biocompatibility, negligible dark toxicity and specific lysosome targeting make
Lyso-CORM
a potent candidate for phototherapeutic applications.
Lyso-CORM
is very stable under dark conditions CO and singlet oxygen generation (
1
O
2
) was effectively triggered under light irradiation conditions. |
---|---|
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d4cc00009a |