A fluorescent spc-covalent organic polymer with an aggregation-induced emission unit to suppress aggregation-induced quenching for sensing furazolidone

Furazolidone (FZD) is a nitrofuran antibiotic that has an inhibitory effect on a variety of Gram-negative and positive bacteria. However, excessive use of FZD can produce major adverse responses and irreversible harm to the central nervous system, so it is necessary to develop a simple, rapid, highly selective and sensitive method for the detection of FZD. Here, a sp 2 c-covalent organic polymer (COP PDAN-BTT ) containing benzotrithiophene was synthesized for fluorescence sensing FZD. The benzotrithiophene in the BTT monomer is a typical aggregation-induced quenching (ACQ) fluorophore, and the cyanide diphenylethylene unit has certain aggregation-induced emission (AIE) properties. The connection of the ACQ fluorophore and the AIE fluorophore can fully improve the ACQ degree of COP PDAN-BTT . Under excitation at 370 nm, COP PDAN-BTT exhibits green fluorescence at 500 nm. Based on the internal filtering effect, COP PDAN-BTT was used for FZD detection. The I 0 / I showed a good linear relationship with the concentration of FZD in the range of 0.034-20 μg mL −1 (0.149-88.9 μM), and the detection limit was as low as 0.011 μg mL −1 (0.049 μM). Based on the AIE properties of COP PDAN-BTT , a fluorescent test strip was prepared for visual detection of FZD. This work provides a simple yet effective method for detection of FZD and improving the fluorescence of COPs. Furazolidone (FZD) is a nitrofuran antibiotic that has an inhibitory effect on a variety of Gram-negative and positive bacteria.