Oxidative cascade cyclization of -arylacrylamides with TMSN
An azido-radical-triggered cyclization of N -( o -cyanobiaryl)acrylamides with TMSN 3 via a C(sp 3 )-N/C(sp 2 )-C(sp 3 )/C(sp 2 )-N bond formation cascade is described. This reaction features mild conditions and high bond-forming efficiency, making it an efficient method for the construction of azid...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2024-02, Vol.22 (6), p.1186-1193 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
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| Zusammenfassung: | An azido-radical-triggered cyclization of
N
-(
o
-cyanobiaryl)acrylamides with TMSN
3
via
a C(sp
3
)-N/C(sp
2
)-C(sp
3
)/C(sp
2
)-N bond formation cascade is described. This reaction features mild conditions and high bond-forming efficiency, making it an efficient method for the construction of azide-substituted pyridophenanthridines.
An azido-radical-triggered cyclization of
N
-(
o
-cyanobiaryl)acrylamides with TMSN
3
for the construction of azide-substituted pyridophenanthridines
via
a C(sp
3
)-N/C(sp
2
)-C(sp
3
)/C(sp
2
)-N bond formation cascade is presented. |
|---|---|
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/d3ob01951a |