Concise syntheses of (−)-habiterpenol and (+)-2,3--habiterpenol redox radical cyclization of alkenylsilane
The concise syntheses of (−)-habiterpenol and (+)-2,3- epi -habiterpenol from (3a R )-(+)-sclareolide and 6-methoxyindanone in 11 and 12 steps, respectively, were enabled by the regioselective addition of the TMS-indenyl anion and the facile stereoselective metal hydride hydrogen atom transfer (MHAT...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2023-08, Vol.21 (3), p.6129-6133 |
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| container_issue | 3 |
| container_start_page | 6129 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 21 |
| creator | Taguchi, Haruki Kawaguchi, Mayuko Nagamitsu, Tohru Ohtawa, Masaki |
| description | The concise syntheses of (−)-habiterpenol and (+)-2,3-
epi
-habiterpenol from (3a
R
)-(+)-sclareolide and 6-methoxyindanone in 11 and 12 steps, respectively, were enabled by the regioselective addition of the TMS-indenyl anion and the facile stereoselective metal hydride hydrogen atom transfer (MHAT)-initiated redox radical cyclization of alkenylsilane.
The concise synthesis of (−)-habiterpenol in 11 steps was enabled by MHAT-initiated redox radical cyclization of alkenylsilane. |
| doi_str_mv | 10.1039/d3ob01062g |
| format | Article |
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)-(+)-sclareolide and 6-methoxyindanone in 11 and 12 steps, respectively, were enabled by the regioselective addition of the TMS-indenyl anion and the facile stereoselective metal hydride hydrogen atom transfer (MHAT)-initiated redox radical cyclization of alkenylsilane.
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)-(+)-sclareolide and 6-methoxyindanone in 11 and 12 steps, respectively, were enabled by the regioselective addition of the TMS-indenyl anion and the facile stereoselective metal hydride hydrogen atom transfer (MHAT)-initiated redox radical cyclization of alkenylsilane.
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)-(+)-sclareolide and 6-methoxyindanone in 11 and 12 steps, respectively, were enabled by the regioselective addition of the TMS-indenyl anion and the facile stereoselective metal hydride hydrogen atom transfer (MHAT)-initiated redox radical cyclization of alkenylsilane.
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| ispartof | Organic & biomolecular chemistry, 2023-08, Vol.21 (3), p.6129-6133 |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Concise syntheses of (−)-habiterpenol and (+)-2,3--habiterpenol redox radical cyclization of alkenylsilane |
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