Palladium-catalyzed domino cyclization/direct functionalization involving the insertion of SO

A reductive cross-coupling strategy for the synthesis of sulfone-containing oxindoles via palladium-catalyzed domino cyclization/alkylsulfonylation reaction of N -substituted arylacrylamides with unactivated alkyl bromides and Na 2 S 2 O 5 is presented. Moreover, using amines instead of alkyl bromides, a palladium-catalyzed domino cyclization/aminosulfonylation was also established. A reductive cross-coupling strategy for the synthesis of sulfone-containing oxindoles was presented. Moreover, using amines instead of alkyl bromides, a palladium-catalyzed domino cyclization/aminosulfonylation was also established.