A linear CH-NO base pair motif promoted by AgNO mediated proton transfer between guanosine and cytidine

Metallo-base pairs are of immense interest. However, uncertainties remain regarding Ag + -nucleic acid component interactions. Instead of a coordinated polymer [C-Ag][NO 3 ] ( 1 ) embedded with Ag + nanowires in an aqueous C/AgNO 3 system, a novel base paired ionic crystal CH + -NO 3 − ( 2 ) was formed in a complex hydrogel system comprising guanosine (G), cytidine (C) and AgNO 3 . The static structural characteristics and underlying coupled reaction mechanisms driving the proton transfer between the G and C in this multi-component system were characterized. This information will be valuable in the context of bio-inorganic chemistry involving G- and C-rich genomic sequences. Harmonious quaternary interactions consisting of G*-Ag and CH + -NO 3 − base pairs are disclosed in a mixed hydrogel system.