Palladium-catalysed deaminative/decarboxylative cross-coupling of organoammonium salts with carboxylic acids

A palladium-catalysed carbon-carbon bond-forming reaction via deaminative/decarboxylative cross-coupling of organoammonium salts with carboxylic acids was developed. Under the reaction conditions, polyfluoroaromatic carboxylic acids, propiolic acids and α-cyano benzyl carboxylic acid reacted smoothly with benzyl ammonium salts to produce the corresponding carbon-carbon coupling products in good-to-excellent yields. A palladium-catalysed C-C bond-forming reaction via deaminative and decarboxylative cross-coupling of organoammonium salts with a series of carboxylic acids (including polyfluoroaromatic, propiolic and α-cyano benzyl carboxylic acids) was developed.