Catalytic redox-neutral C-H functionalisation with TEMPO in water to access aminomethyl-substituted pyrroles

Catalytic redox-neutral C-H functionalisation with TEMPO in water to access aminomethyl-substituted pyrroles

A redox-neutral C-H functionalisation in water employing catalytic TEMPO to synthesize aminomethyl-substituted pyrroles is reported. Starting from cheap and commercial chemical feedstocks (ketoesters and anilines), our approach delivered targeted products in good yields and represents an endeavour t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic & biomolecular chemistry 2022-05, Vol.2 (17), p.3495-35
Hauptverfasser: Cariello Silva, Guilherme, de Souza, Gabriela F. P, Salles, Airton G
Format: Artikel
Sprache:eng
Schlagworte:
Aniline
Chemical synthesis
Cyclic N-Oxides
Ketoesters
Molecular Structure
Oxidation-Reduction
Pyrroles
Substitutes
Water
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A redox-neutral C-H functionalisation in water employing catalytic TEMPO to synthesize aminomethyl-substituted pyrroles is reported. Starting from cheap and commercial chemical feedstocks (ketoesters and anilines), our approach delivered targeted products in good yields and represents an endeavour to address redox economy in radical transformations. A redox-neutral C-H functionalisation in water employing catalytic TEMPO to synthesize aminomethyl-substituted pyrroles is reported.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob00574c