A -Pt() hedgehog pathway inhibitor complex with cytotoxicity towards breast cancer stem cells and triple negative breast cancer cells

The first example of a Pt complex of GANT61, a hedgehog (Hh) pathway inhibitor is reported. Reaction of cis -[Pt( ii )Cl 2 (dmso) 2 ] with one equivalent of 4-pyridine carboxaldehyde (4-PCA, control ligand) or one equivalent of GANT61 (Hh pathway inhibitor) in acetone at rt for 30 minutes afforded t...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2022-12, Vol.51 (47), p.18127-18135
Hauptverfasser:	Ryan, Aisling L, Northcote-Smith, Joshua, McKeon, Aoife, Roe, Andrew, O'Dowd, Paul, Twamley, Brendan, Ní Chonghaile, Triona, Suntharalingam, Kogularamanan, Griffith, Darren M
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