A hypoxia-activated photothermal agent inhibits multiple heat shock proteins for low-temperature photothermal therapy

A hypoxia-activated photothermal agent inhibits multiple heat shock proteins for low-temperature photothermal therapy

A near-infrared (NIR) organic photothermal agent (PTA) to inhibit three types of heat shock proteins (HSPs) was synthesized, which could be activated under hypoxic conditions for low-temperature photothermal therapy (PTT) of cancer. A hypoxia-activated photothermal agent to suppress the expression o...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2023-03, Vol.59 (26), p.3898-391
Hauptverfasser: Zhang, Xinhao, Xue, Shan-Shan, Pan, Wei, Wang, Kaiye, Li, Na, Tang, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line, Tumor
Heat shock proteins
Humans
Hypoxia
Hypoxia - therapy
Low temperature
Nanoparticles
Neoplasms - metabolism
Phototherapy
Photothermal Therapy
Temperature
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Zusammenfassung:A near-infrared (NIR) organic photothermal agent (PTA) to inhibit three types of heat shock proteins (HSPs) was synthesized, which could be activated under hypoxic conditions for low-temperature photothermal therapy (PTT) of cancer. A hypoxia-activated photothermal agent to suppress the expression of multiple heat shock proteins was synthesized for low-temperature photothermal therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc06598c