Rationally designed Ru() metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer

Herein, we construct a series of Ru( ii ) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru( ii ) metallacycles in biomedicine. Herein, we construct a series of Ru( ii ) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin.