Photoredox synthesis of 6- and 7-membered ring scaffolds -centered radicals
N -Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds. Their synthesis has been considered as an important research field. In this work we report the access to 6- and 7-membered rings via a photoinduced strategy. To our knowledge, this work repres...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2022-08, Vol.58 (66), p.926-929 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
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Zusammenfassung: | N
-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds. Their synthesis has been considered as an important research field. In this work we report the access to 6- and 7-membered rings
via
a photoinduced strategy. To our knowledge, this work represents the first exemple of photo-induced 7-
endo
-trig cyclization with
N
-centered radicals.
Nitrogen-centered radicals are an important way to build C-N bonds. Herein, the synthesis of 6- and 7-membered rings, which are really scarce in the literature, through visible light irradiation using a photoredox strategy was achieved. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d2cc02780a |