Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-bind...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-06, Vol.58 (53), p.7384-7387
Hauptverfasser: Coverdale, James P. C, van den Berg, Hugo A, Khazaipoul, Siavash, Bridgewater, Hannah E, Stewart, Alan J, Blindauer, Claudia A
Format: Artikel
Sprache:eng
Schlagworte:
Albumins
Chemistry
Endothelial cells
Fatty acids
Speciation
Zinc
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Zusammenfassung:The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux. Fatty acids alter zinc speciation in plasma, increasing zinc influx into endothelial cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc02278h