Access to benzene-modified 2 generation strigolactams and GR24 by merging C-H olefination with decarboxylative Giese cyclization

Herein, we reported an efficient and general synthetic route to assemble benzene-modified 2 nd generation strigolactams and GR24. The key features of this synthesis include a palladium-catalyzed ortho -selective olefination of the commercially available substituted N -Boc phenylalanine and a decarboxylative Giese radical cyclization. The bioactivities of these compounds to stimulate the seed germination of Orobanche aegyptiaca parasitic weed were also analysed. 2 nd generation strigolactam 15f derived from para -OMe phenylalanine showed superior bioactivity to the original unsubstituted 15b . Herein, we reported an efficient and general synthetic route to assemble benzene-modified 2 nd generation strigolactams and GR24. The key features of this synthesis include a palladium-catalyzed ortho -selective olefination and a decarboxylative Giese radical cyclization.