Enhanced C NMR detects extended reaction networks in living cells

Enhanced C NMR detects extended reaction networks in living cells

Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13 C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densiti...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (81), p.1572-1575
Hauptverfasser: Jensen, Pernille Rose, Sannelli, Francesca, Stauning, Ludvig Tving, Meier, Sebastian
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container_issue 81
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container_title Chemical communications (Cambridge, England)
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creator Jensen, Pernille Rose
Sannelli, Francesca
Stauning, Ludvig Tving
Meier, Sebastian
description Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13 C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells. Mechanistic insights into the chemistry of life can be advanced by compounding physical labelling and high-sensitivity detection.
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title Enhanced C NMR detects extended reaction networks in living cells
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