KSO activation by glucose at room temperature for the synthesis and functionalization of heterocycles in water

While persulfate activation at room temperature using glucose has primarily been focused on kinetic studies of the sulfate radical anion, the utilization of this protocol in organic synthesis is rarely demonstrated. We reinvestigated selected K 2 S 2 O 8 -mediated known organic reactions that invariably require higher temperatures and an organic solvent. A diverse, mild functionalization and synthesis of heterocycles using the inexpensive oxidant K 2 S 2 O 8 in water at room temperature is reported, demonstrating the sustainability and broad scope of the method. Unlike traditional methods used for persulfate activation, the current method uses naturally abundant glucose as a K 2 S 2 O 8 activator, avoiding the use of higher temperature, UV light, transition metals or bases. A diverse functionalization and synthesis of heterocycles using K 2 S 2 O 8 as oxidant and glucose as persulfate activator in water at room temperature is reported.