A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy

A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy

Herein, we report, for the first time, a Pd 6 L 8 (NO 3 ) 5.4 (ICG) 6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate ( 3 ) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered 1 O 2 generation, high c...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-08, Vol.57 (64), p.7954-7957
Hauptverfasser: Li, Wen-Yan, Zhao, Chao-Wei, Zhang, Yue-Feng, Guan, Qun, Wan, Jing-Jing, Ma, Jian-Ping, Li, Yan-An, Dong, Yu-Bin
Format: Artikel
Sprache:eng
Schlagworte:
Anion exchanging
Cages
Crystallography
Infrared radiation
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Zusammenfassung:Herein, we report, for the first time, a Pd 6 L 8 (NO 3 ) 5.4 (ICG) 6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate ( 3 ) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered 1 O 2 generation, high cellular uptake selective lysosome-targeting ability, and, consequently, excellent antineoplastic activity. A Pd 6 L 8 (NO 3 ) 5.4 (ICG) 6.6 -based nanoagent (ICG = indocyanine green) displays a highly efficient antitumor activity due to its enhanced NIR light-triggered 1 O 2 generation, high cellular uptake, and selective lysosome-targeting ability.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc02629a