Novel -transfer reagent for converting α-amino acid derivatives to α-diazo compounds

A novel universal N -transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides from N -terminal dipeptides (32 examples, up to 91%). N -Atom is delivered to an amine to synthesize α-diazo compounds through triazene fragmentation.