Metal-free efficient thiolation of C(sp) functionalization -generated NHTS for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole

A direct metal-free approach for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole derivatives at room temperature is reported via an in situ -generated electrophilic thiolating agent. The present protocol provides mild and selective access for the insertion of C-S bond functionalization with good yield. The mechanistic path was justified via density functional theory (DFT) calculations, which explore the role of the solvent in the reaction mechanism. A direct metal-free approach for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole derivatives at room temperature is reported via an in situ -generated electrophilic thiolating agent.