Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions. A mitochon...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (92), p.14491-14494
Hauptverfasser: Wu, Canchen, Wang, Danqi, Cen, Moupan, Cao, Leyu, Ding, Yue, Wang, Jin, Yuan, Xiaolei, Wang, Yang, Chen, Tingting, Yao, Yong
Format: Artikel
Sprache:eng
Schlagworte:
Copper sulfides
Mitochondria
Nanogenerators
Nitric oxide
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Zusammenfassung:An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions. A mitochondria-targeting NO gas-releasing nanoplatform based on CuS-nanoplates has been designed for augmenting photothermal therapy by the synergistic effect.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05125j