A two-photon responsive naphthyl tagged -hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

We report a two-photon responsive drug delivery system (DDS), namely, p -hydroxyphenacyl-naphthalene-chlorambucil ( p HP-Naph-Cbl ), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release. A two-photon responsive drug delivery system having two-photon absorption (TPA) in the phototherapeutic window with a two-photon uncaging cross-section ≥10 GM and exhibiting real-time monitoring of anti-cancer drug release.