Chiral bisphosphine ligands based on quinoline oligoamide foldamers: application in asymmetric hydrogenation

A series of chiral bisphosphine ligands were designed and synthesized based on single-handed quinoline oligoamide foldamers. The bisphosphine ligands can coordinate with Rh(cod) 2 BF 4 in a 1 : 1 stoichiometry and the resulted chiral Rh( i ) catalysts were applied in the asymmetric hydrogenation of α-dehydroamino acid esters, in which excellent conversions and promising levels of enantioselectivity were achieved. Single-handed quinoline oligoamide foldamer-based bisphosphine ligands that can coordinate with Rh(cod) 2 BF 4 were used as a platform in asymmetric hydrogenation.