Highly regioselective α-formylation and α-acylation of BODIPY dyes tandem cross-dehydrogenative coupling with deprotection

A metal-free C-H formylation and acylation of BODIPY dyes using a variety of dioxolane derivatives as aldehyde equivalents is reported, providing a postfunctionalization method for controllable synthesis of BODIPYs with carbonyl groups at 3,5-positions via a radical process. The photophysical properties of resultant dyes from this efficient one-pot, chemo- and site-selective transformation have been studied. An efficient protocol for the regioselective C-H α-formylation and α-acylation of BODIPY dyes using dioxolane derivatives as aldehyde equivalents is reported.