The electrochemical investigation of carboxamide-PEG-biotin-CoPc using composite MWCNTs on modified GCE: the sensitive detections for glucose and hydrogen peroxide

The electroanalytical study of a synthesized novel tetra-cobalt( ii ) carboxamide-PEG 2 -biotin phthalocyanine (CoTPEG 2 BAPc) composite with MWCNTs to create a biosensor with a high response to glucose in the presence of H 2 O 2 . The glucose biosensor can be easily detected by casting onto GCE, and and it displays intrinsic electrocatalytic ability for the enzymatic oxidation and reduction of glucose and H 2 O 2 , showing higher catalytic activity than that of a bulk CoTPEG 2 BAPc electrode. Under optimal conditions, the biosensor shows a wide linear response to glucose (CV: 2-16; DPV: 2-22; CA: 5-50 μmol) and H 2 O 2 (CV: 5-25; DPV: 2-22; CA: 5-50 μmol), good sensitivity towards glucose (CV: 0.947; DPV: 1.978; CA: 0.101 μA μM −1 cm −2 ) and H 2 O 2 (CV: 1.250; DPV: 1.888; CA: 0.162 μA μM −1 cm −2 ), and a stable long-term life and LOD for glucose (CV: 0.33; DPV: 2; CA: 12.5 μmol L −1 ) and H 2 O 2 (CV: 1.5; DPV: 5; CA: 10 μmol L −1 ). The amperometry selectivity studies involving different biomolecules, including AA, DA, UA, l -cysteine, and glycine, show that they do not affect glucose and H 2 O 2 determination. Our present work exhibits very attractive and practical performance for biosensor applications. The electroanalytical study of a synthesized novel tetra-cobalt( ii ) carboxamide-PEG 2 -biotin phthalocyanine (CoTPEG 2 BAPc) composite with MWCNTs to create a biosensor with a high response to glucose in the presence of H 2 O 2 .