Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery
The anticancer drug 6-MP was covalently bonded to the OH group of poly(HPMA) via a glutathione-responsive carbonyl vinyl sulfide linker. In vitro simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells. GSH-sensitive poly(HPMA)PTA...
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| Veröffentlicht in: | New journal of chemistry 2019-08, Vol.43 (31), p.12215-1222 |
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| container_end_page | 1222 |
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| container_issue | 31 |
| container_start_page | 12215 |
| container_title | New journal of chemistry |
| container_volume | 43 |
| creator | Xu, Weibing Li, Guichen Long, Haitao Fu, Guorui Pu, Lumei |
| description | The anticancer drug 6-MP was covalently bonded to the OH group of poly(HPMA)
via
a glutathione-responsive carbonyl vinyl sulfide linker.
In vitro
simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells.
GSH-sensitive poly(HPMA)PTA was developed and its antitumor effect on HepG2 cells was evaluated. |
| doi_str_mv | 10.1039/c9nj02582k |
| format | Article |
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via
a glutathione-responsive carbonyl vinyl sulfide linker.
In vitro
simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells.
GSH-sensitive poly(HPMA)PTA was developed and its antitumor effect on HepG2 cells was evaluated.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/c9nj02582k</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Assaying ; Carbonyls ; Conjugates ; Glutathione ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Photon correlation spectroscopy ; Zeta potential</subject><ispartof>New journal of chemistry, 2019-08, Vol.43 (31), p.12215-1222</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-797f06378dfe5aa0a1285a26b6147d6c1509c03e264c44dbafd44229079724a63</citedby><cites>FETCH-LOGICAL-c281t-797f06378dfe5aa0a1285a26b6147d6c1509c03e264c44dbafd44229079724a63</cites><orcidid>0000-0002-1348-9314</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Xu, Weibing</creatorcontrib><creatorcontrib>Li, Guichen</creatorcontrib><creatorcontrib>Long, Haitao</creatorcontrib><creatorcontrib>Fu, Guorui</creatorcontrib><creatorcontrib>Pu, Lumei</creatorcontrib><title>Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery</title><title>New journal of chemistry</title><description>The anticancer drug 6-MP was covalently bonded to the OH group of poly(HPMA)
via
a glutathione-responsive carbonyl vinyl sulfide linker.
In vitro
simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells.
GSH-sensitive poly(HPMA)PTA was developed and its antitumor effect on HepG2 cells was evaluated.</description><subject>Anticancer properties</subject><subject>Assaying</subject><subject>Carbonyls</subject><subject>Conjugates</subject><subject>Glutathione</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Photon correlation spectroscopy</subject><subject>Zeta potential</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpFkD1PwzAURS0EEqWwsCNZYgGkgJ_tOPFYVVA-WuhA58h1bEgIdrATpP57AkUwvTuce590EDoGcgmEySstXU1omtO3HTQCJmQiqYDdIQPnCUm52EcHMdaEAGQCRmg1a_pOda-VdwYHE1vvYvVpcOubzdntcjE5x9q7un9RncFOOd-q0FW6MRFbH7CxttKVcR0WyWKJS9MM5bA5RHtWNdEc_d4xWt1cP09vk_nT7G46mSea5tAlmcwsESzLS2tSpYgCmqeKirUAnpVCQ0qkJsxQwTXn5VrZknNKJRmKlCvBxuh0u9sG_9Gb2BW174MbXhaUipyRFCQfqIstpYOPMRhbtKF6V2FTACm-tRVT-Xj_o-1hgE-2cIj6j_vXyr4AvYVo0A</recordid><startdate>20190805</startdate><enddate>20190805</enddate><creator>Xu, Weibing</creator><creator>Li, Guichen</creator><creator>Long, Haitao</creator><creator>Fu, Guorui</creator><creator>Pu, Lumei</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-1348-9314</orcidid></search><sort><creationdate>20190805</creationdate><title>Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery</title><author>Xu, Weibing ; Li, Guichen ; Long, Haitao ; Fu, Guorui ; Pu, Lumei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-797f06378dfe5aa0a1285a26b6147d6c1509c03e264c44dbafd44229079724a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Assaying</topic><topic>Carbonyls</topic><topic>Conjugates</topic><topic>Glutathione</topic><topic>Nanoparticles</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Photon correlation spectroscopy</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Weibing</creatorcontrib><creatorcontrib>Li, Guichen</creatorcontrib><creatorcontrib>Long, Haitao</creatorcontrib><creatorcontrib>Fu, Guorui</creatorcontrib><creatorcontrib>Pu, Lumei</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Weibing</au><au>Li, Guichen</au><au>Long, Haitao</au><au>Fu, Guorui</au><au>Pu, Lumei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery</atitle><jtitle>New journal of chemistry</jtitle><date>2019-08-05</date><risdate>2019</risdate><volume>43</volume><issue>31</issue><spage>12215</spage><epage>1222</epage><pages>12215-1222</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>The anticancer drug 6-MP was covalently bonded to the OH group of poly(HPMA)
via
a glutathione-responsive carbonyl vinyl sulfide linker.
In vitro
simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells.
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| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2019-08, Vol.43 (31), p.12215-1222 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_rsc_primary_c9nj02582k |
| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Anticancer properties Assaying Carbonyls Conjugates Glutathione Nanoparticles NMR Nuclear magnetic resonance Photon correlation spectroscopy Zeta potential |
| title | Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery |
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