Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

The anticancer drug 6-MP was covalently bonded to the OH group of poly(HPMA) via a glutathione-responsive carbonyl vinyl sulfide linker. In vitro simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells. GSH-sensitive poly(HPMA)PTA...

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Veröffentlicht in:New journal of chemistry 2019-08, Vol.43 (31), p.12215-1222
Hauptverfasser: Xu, Weibing, Li, Guichen, Long, Haitao, Fu, Guorui, Pu, Lumei
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Assaying
Carbonyls
Conjugates
Glutathione
Nanoparticles
NMR
Nuclear magnetic resonance
Photon correlation spectroscopy
Zeta potential
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Zusammenfassung:The anticancer drug 6-MP was covalently bonded to the OH group of poly(HPMA) via a glutathione-responsive carbonyl vinyl sulfide linker. In vitro simulation assay demonstrated that the poly(HPMA)PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells. GSH-sensitive poly(HPMA)PTA was developed and its antitumor effect on HepG2 cells was evaluated.
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj02582k