Copper-catalyzed asymmetric silyl addition to alkenyl-substituted -heteroarenes

Asymmetric conjugate addition of PhMe 2 SiBPin to a wide range of N -heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N -heteroarenes in high yields (up to 96%) and excellent enantioselectivities (up to 97% ee). Asymmetric conjugate addition of PhMe 2 SiBPin to a wide range of N -heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with a chiral phosphoramidite ligand to afford useful β-silyl N -heteroarenes in high yields and ees.