A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-11, Vol.55 (95), p.14387-1439
Hauptverfasser: Gao, Jie, Yu, Huijuan, Chen, Fang-Yuan, Hu, Xin-Yue, Wang, Yuefei, Guo, Dong-Sheng
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphate - chemistry
Adenosine Triphosphate - metabolism
Biomarkers
Biomarkers, Tumor - chemistry
Biomarkers, Tumor - metabolism
Calixarenes - chemistry
Calixarenes - metabolism
Dismantling
Eosine Yellowish-(YS) - chemistry
Eosine Yellowish-(YS) - metabolism
Guanidine - chemistry
Guanidine - metabolism
Humans
Hyaluronic acid
Hyaluronic Acid - chemistry
Hyaluronic Acid - metabolism
Hyaluronoglucosaminidase - chemistry
Hyaluronoglucosaminidase - metabolism
Macromolecular Substances - chemistry
Macromolecular Substances - metabolism
Polymers - chemistry
Polymers - metabolism
Stimuli
Theranostic Nanomedicine
Tumor Microenvironment
Tumors
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Zusammenfassung:We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics. We designed a hyaluronidase/ATP tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene and eosin Y modified hyaluronic acid.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc08199b