Bi(OAc)/chiral phosphoric acid catalyzed enantioselective allylation of isatins

Bi(OAc)/chiral phosphoric acid catalyzed enantioselective allylation of isatins

Herein, we disclosed an efficient protocol for the construction of chiral 3-allyl-3-hydroxyoxindoles via the enantioselective allylation reaction of isatins and allylboronates catalyzed by a simple binary acid Bi(OAc) 3 /CPA system under mild conditions. The synthetic utility of this strategy has be...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (2), p.261-264
Hauptverfasser: Wang, Jie, Zhang, Qingxia, Li, Yao, Liu, Xiangshuai, Li, Xin, Cheng, Jin-Pei
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Sprache:eng
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Zusammenfassung:Herein, we disclosed an efficient protocol for the construction of chiral 3-allyl-3-hydroxyoxindoles via the enantioselective allylation reaction of isatins and allylboronates catalyzed by a simple binary acid Bi(OAc) 3 /CPA system under mild conditions. The synthetic utility of this strategy has been demonstrated through the formal synthesis of ent -CPC-1. Herein, we disclosed an efficient protocol for the construction of chiral 3-allyl-3-hydroxyoxindoles via the enantioselective allylation reaction of isatins and allylboronates catalyzed by a simple binary acid Bi(OAc) 3 /CPA system under mild conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07944k