Rhodium-mediated F-oxyfluorination of diazoketones using a fluorine-18-containing hypervalent iodine reagent
Geminal 18 F-oxyfluorination of diazoketones was performed in the presence of rhodium mediators. The reactions were performed using a hypervalent iodine-based [ 18 F]fluoro-benziodoxole reagent. By this methodology various -[ 18 F]fluoro ethers were obtained in high radiochemical yield (up to 98%) a...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2019-11, Vol.55 (89), p.13358-13361 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Geminal
18
F-oxyfluorination of diazoketones was performed in the presence of rhodium mediators. The reactions were performed using a hypervalent iodine-based [
18
F]fluoro-benziodoxole reagent. By this methodology various -[
18
F]fluoro ethers were obtained in high radiochemical yield (up to 98%) and molar activity (216 GBq mol
1
).
-[
18
F]Fluoro ethers were obtained from diazocarbonyl compounds using a hypervalent iodine based fluorine-18 reagent. |
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| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/c9cc06905d |